Publications

2024

Wu CT, Du D, Chen L, Dai R, Liu C, Yu G, Bhardwaj S, Parker SJ, Zhang Z, Clarke R, Herrington DM, Wang Y. CAM3.0: determining cell type composition and expression from bulk tissues with fully unsupervised deconvolution. Bioinformatics. 2024 Mar 4;40(3):btae107. doi: 10.1093/bioinformatics/btae107. PMID: 38407991; PMCID: PMC10924278.

Lawal OO, Ulloa Severino FP, Wang S, Bindu DS, Sakers K, Johnson SA, Yin HH, Eroglu C. Astrocytic thrombospondins 1 and 2 are required for cortical synapse development controlling instrumental performance. bioRxiv 2024.03.01.582935; doi: https://doi.org/10.1101/2024.03.01.582935\

2023

Barclay KM, Abduljawad N, Cheng Z, Kim MW, Zhou L, Yang J, Rustenhoven J, Perez JM, Smyth L, Beatty W, Hou J, Saligrama N, Colonna M, Yu G, Kipnis J, Li Q. An inducible genetic tool for tracking and manipulating specific microglial states in development and disease. bioRxiv [Preprint]. 2023 Dec 4:2023.12.01.569597. doi: 10.1101/2023.12.01.569597. PMID: 38106187; PMCID: PMC10723357.

Tan CX, Bindu DS, Hardin EJ, Sakers K, Baumert R, Ramirez JJ, Savage JT, Eroglu C. ?-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions. J Cell Biol. 2023 Nov 6;222(11):e202303138. doi: 10.1083/jcb.202303138. Epub 2023 Sep 14. PMID: 37707499; PMCID: PMC10501387.

Ulloa Severino FP, Lawal OO, Sakers K, Wang S, Kim N, Friedman AD, Johnson SA, Sriworarat C, Hughes RH, Soderling SH, Kim IH, Yin HH, Eroglu C. Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control. Nat Commun. 2023 Sep 8;14(1):5522. doi: 10.1038/s41467-023-41078-z. PMID: 37684234; PMCID: PMC10491649.

Zhang SX, Kim A, Madara JC, Zhu PK, Christenson LF, Lutas A, Kalugin PN, Jin Y, Pal A, Tian L, Lowell BB, Andermann ML. Competition between stochastic neuropeptide signals calibrates the rate of satiation.
Res Sq [Preprint]. 2023 Jul 26:rs.3.rs-3185572. doi: 10.21203/rs.3.rs-3185572/v1. PMID: 37546985; PMCID: PMC10402269.

Du D, Bhardwaj S, Parker SJ, Cheng Z, Zhang Z, Lu Y, Van Eyk JE, Yu G, Clarke R, Herrington DM, Wang Y.
ABDS: tool suite for analyzing biologically diverse samples. bioRxiv [Preprint]. 2023 Jul 5:2023.07.05.547797. doi: 10.1101/2023. 07.05.547797. PMID: 37461566; PMCID: PMC10349978.

Andreoni A, Tian L. Lighting up action potentials with fast and bright voltage sensors. Nat Methods. 2023 Jul;20(7):990-992. doi: 10.1038/s41592-023-01928-6. PMID:37429963.

Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY,Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, LefevreA, Singh VP, Arokiaraj CM, Shay TF, VendemiattiJ, Jang MJ, Mich JK, Bishaw Y, GoreBB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J,Tian L, Fox AS, Gradinaru V. Adeno-associated viral vectors forfunctional intravenousgene transfer throughout the non-human primate brain. Nat Nanotechnol. 2023 Jul 10.doi: 10.1038/s41565-023-01419-x. Epub ahead of print. PMID: 37430038.

Lin Tian, Chunyang Dong, Raajaram Gowrishankar et al. Unlocking opioidneuropeptide dynamics with genetically-encoded biosensors, 30 May 2023,PREPRINT (Version 1) available at Research Square[https://doi.org/10.21203/rs.3.rs-2871083/v1]

Savage JT, Ramirez J, Risher WC, Irala D, Eroglu C. SynBot: An open-source imageanalysis software for automated quantification of synapses. bioRxiv [Preprint]. 2023Jun 28:2023.06.26.546578. doi: 10.1101/2023.06.26.546578. PMID: 37425715; PMCID:PMC10327002.

Left: An immune brain cell (microglia) in a human brain. Right: Microglia in the novel organoid model with a human-brain-like environment. The cells are almost indistinguishable.Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 May 11;186(10):2111-2126.e20. doi: 10.1016/j.cell.2023.04.022. PMID: 37172564.

Irala D, Wang S, Sakers K, Nagendren L, Ulloa-Severino FP, Bindu DS, Eroglu C. Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function. bioRxiv [Preprint]. 2023 Apr 3:2023.04.03.535448. doi: 10.1101/2023.04.03.535448. PMID: 37066164; PMCID: PMC10104008.

Reitman ME, Tse V, Mi X, Willoughby DD, Peinado A, Aivazidis A, Myagmar BE, Simpson PC, Bayraktar OA, Yu G, Poskanzer KE. Norepinephrine links astrocytic activity to regulation of cortical state. Nat Neurosci. 2023 Apr;26(4):579-593. doi: 10.1038/s41593-023-01284-w. Epub 2023 Mar 30. PMID: 36997759; PMCID: PMC10089924.

wearable microscopeShekhtmeyster P, Carey EM, Duarte D, Ngo A, Gao G, Nelson NA, Clark CL, Nimmerjahn A. Multiplex translaminar imaging in the spinal cord of behaving mice. Nat Commun. 2023 Mar 21;14(1):1427. doi: 10.1038/s41467-023-36959-2. PMID: 36944637; PMCID: PMC10030868.

Shekhtmeyster P, Duarte D, Carey EM, Ngo A, Gao G, Olmstead JA, Nelson NA, Nimmerjahn A. Trans-segmental imaging in the spinal cord of behaving mice. Nat Biotechnol. 2023 Mar 6. doi: 10.1038/s41587-023-01700-3. Epub ahead of print. PMID: 36879007.

mouse gene editingBindu DS, Tan CX, Savage JT, Eroglu C. GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes. bioRxiv [Preprint]. 2023 Jan 19:2023.01.17.524433. doi: 10.1101/2023.01.17.524433. PMID: 36711516; PMCID: PMC9884502.

Chen X, Wolfe DA, Sivadasan Bindu D et al. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523844. doi: 10.1101/2023.01.12.523844. PMID: 36711773; PMCID: PMC9882234.

2022

Chen G, Xu J, Luo H, Luo X, Singh SK, Ramirez JJ, James ML, Mathew JP, Berger M, Eroglu C, Ji RR. Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. JCI Insight. 2022 Dec 8;7(23):e161028. doi: 10.1172/jci.insight.161028. PMID: 36256481; PMCID: PMC9746899.

GLIA coverNimmerjahn A, Hirrlinger J. Astrocyte regulation of neural circuit function and animal behavior. Glia. 2022 Aug;70(8):1554-1580. doi: 10.1002/glia.24168. Epub 2022 Mar 17. PMID: 35297525; PMCID: PMC9291267.

Hirrlinger J, Nimmerjahn A. A perspective on astrocyte regulation of neural circuit function and animal behavior. Glia. 2022 Aug;70(8):1554-1580. doi: 10.1002/glia.24168. Epub 2022 Mar 17. PMID: 35297525; PMCID: PMC9291267.

Lawal O, Ulloa Severino FP, Eroglu C. The role of astrocyte structural plasticity in regulating neural circuit function and behavior. Glia. 2022 Aug;70(8):1467-1483. doi: 10.1002/glia.24191. Epub 2022 May 10. PMID: 35535566; PMCID: PMC9233050.

neurophotonics coverAbdelfattah AS, Ahuja S, Akkin T, et al. Neurophotonic tools for microscopic measurements and manipulation: status report. Neurophotonics. 2022 Jan;9(Suppl 1):013001. doi: 10.1117/1.NPh.9.S1.013001. Epub 2022 Apr 27. PMID: 35493335; PMCID: PMC9047450.

2021

Shekhtmeyster P, Duarte D, Carey EM, Ngo A, Gao G, Olmstead JA, Nelson NA, Nimmerjahn A. Trans-segmental imaging in the spinal cord of behaving mice. bioRxiv 2021.12.23.474042; doi: https://doi.org/10.1101/2021.12.23.474042

Shekhtmeyster P, Carey EM, Duarte D, Ngo A, Grace Gao, Nelson NA, Clark CL, Nimmerjahn A. Multiplex, translaminar imaging in the spinal cord of behaving mice. bioRxiv 2021.12.23.474039; doi: https://doi.org/10.1101/2021.12.23.474039

Merten K, Folk RW, Duarte D, Nimmerjahn A. Astrocytes encode complex behaviorally relevant information. bioRxiv 2021.10.09.463784; doi: https://doi.org/10.1101/2021.10.09.463784?